Cathay Pacific will add a fourth daily non-stop flight from Hong Kong to Los Angeles in June and will add three weekly Chicago non-stop routings in August, pending government approval.
The flights will be operated on Boeing 777-300ER aircraft.
The airline previously announced it would be adding daily service to Newark in March.
“North America is an important market for Cathay Pacific, and we are pleased to be able to expand our services further and provide even more options for travelers," the carrier's chief executive, John Slosar, said in a statement. "Los Angeles and Chicago are important gateway cities in the United States."